Publications

2010

Brafman, David A., Chien W. Chang, Antonio Fernandez, Karl Willert, Shyni Varghese, and Shu Chien. “Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces.” Biomaterials 31, no. 34 (December 2010): 9135–44. https://doi.org/10.1016/j.biomaterials.2010.08.007.

Chang, C. W., A. Van Spreeuwel, C. Zhang, and S. Varghese. “PEG/clay nanocomposite hydrogel: A mechanically robust tissue engineering scaffold.” Soft Matter 6, no. 20 (October 21, 2010): 5157–64. https://doi.org/10.1039/c0sm00067a.

Hwang, Yongsung, Nivedita Sangaj, and Shyni Varghese. “Interconnected macroporous poly(ethylene glycol) cryogels as a cell scaffold for cartilage tissue engineering.” Tissue Eng Part A 16, no. 10 (October 2010): 3033–41. https://doi.org/10.1089/ten.TEA.2010.0045.

Phadke, Ameya, Chao Zhang, Yongsung Hwang, Kenneth Vecchio, and Shyni Varghese. “Templated mineralization of synthetic hydrogels for bone-like composite materials: role of matrix hydrophobicity.” Biomacromolecules 11, no. 8 (August 9, 2010): 2060–68. https://doi.org/10.1021/bm100425p.

Brammer, K. S., S. Oh, C. J. Frandsen, S. Varghese, and S. Jin. “Nanotube surface triggers increased chondrocyte extracellular matrix production.” Materials Science and Engineering C 30, no. 4 (May 10, 2010): 518–25. https://doi.org/10.1016/j.msec.2010.01.013.

Varghese, Shyni, Nathaniel S. Hwang, Angela Ferran, Alexander Hillel, Parnduangjai Theprungsirikul, Adam C. Canver, Zijun Zhang, John Gearhart, and Jennifer Elisseeff. “Engineering musculoskeletal tissues with human embryonic germ cell derivatives.” Stem Cells 28, no. 4 (April 2010): 765–74. https://doi.org/10.1002/stem.325.

Hwang, Y., C. Zhang, and S. Varghese. “Poly(ethylene glycol) cryogels as potential cell scaffolds: Effect of polymerization conditions on cryogel microstructure and properties.” Journal of Materials Chemistry 20, no. 2 (January 1, 2010): 345–51. https://doi.org/10.1039/b917142h.

Phadke, A., C. W. Chang, and S. Varghese. “Functional Biomaterials for Controlling Stem Cell Differentiation.” In Studies in Mechanobiology, Tissue Engineering and Biomaterials, 2:19–44, 2010. https://doi.org/10.1007/8415_2010_2.

2009

Zhang, C., A. Aung, L. Liao, and S. Varghese. “A novel single precursor-based biodegradable hydrogel with enhanced mechanical properties.” Soft Matter 5, no. 20 (October 21, 2009): 3831–34. https://doi.org/10.1039/b912102a.

Hillel, Alexander T., Shyni Varghese, Jennifer Petsche, Michael J. Shamblott, and Jennifer H. Elisseeff. “Embryonic germ cells are capable of adipogenic differentiation in vitro and in vivo.” Tissue Eng Part A 15, no. 3 (March 2009): 479–86. https://doi.org/10.1089/ten.tea.2007.0352.

Hwang, Nathaniel S., Chao Zhang, Yong-Sung Hwang, and Shyni Varghese. “Mesenchymal stem cell differentiation and roles in regenerative medicine.” Wiley Interdiscip Rev Syst Biol Med 1, no. 1 (2009): 97–106. https://doi.org/10.1002/wsbm.26.

2008

Hwang, Nathaniel S., Shyni Varghese, H Janice Lee, Zijun Zhang, Zhaohui Ye, Jongwoo Bae, Linzhao Cheng, and Jennifer Elisseeff. “In vivo commitment and functional tissue regeneration using human embryonic stem cell-derived mesenchymal cells.” Proc Natl Acad Sci U S A 105, no. 52 (December 30, 2008): 20641–46. https://doi.org/10.1073/pnas.0809680106.

Lee, H. J., C. Yu, T. Chansakul, N. S. Hwang, S. Varghese, S. M. Yu, and J. H. Elisseeff. “Enhanced chondrogenesis of mesenchymal stem cells in collagen mimetic peptide-mediated microenvironment.” Tissue Engineering - Part A. 14, no. 11 (November 1, 2008): 1843–51. https://doi.org/10.1089/ten.tea.2007.0204.

Hwang, Nathaniel S., Shyni Varghese, and Jennifer Elisseeff. “Derivation of chondrogenically-committed cells from human embryonic cells for cartilage tissue regeneration.” PLoS One 3, no. 6 (June 25, 2008): e2498. https://doi.org/10.1371/journal.pone.0002498.

Lee, H Janice, Christopher Yu, Thanissara Chansakul, Shyni Varghese, Nathaniel S. Hwang, and Jennifer H. Elisseeff. “Enhanced chondrogenic differentiation of embryonic stem cells by coculture with hepatic cells.” Stem Cells Dev 17, no. 3 (June 2008): 555–63. https://doi.org/10.1089/scd.2007.0177.

Hwang, Nathaniel S., Shyni Varghese, and Jennifer Elisseeff. “Controlled differentiation of stem cells.” Adv Drug Deliv Rev 60, no. 2 (January 14, 2008): 199–214. https://doi.org/10.1016/j.addr.2007.08.036.

Varghese, Shyni, Nathaniel S. Hwang, Adam C. Canver, Parnduangji Theprungsirikul, Debora W. Lin, and Jennifer Elisseeff. “Chondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells.” Matrix Biol 27, no. 1 (January 2008): 12–21. https://doi.org/10.1016/j.matbio.2007.07.002.

2007

Hwang, Nathaniel S., Shyni Varghese, H Janice Lee, Parnduangjai Theprungsirikul, Adam Canver, Blanka Sharma, and Jennifer Elisseeff. “Response of zonal chondrocytes to extracellular matrix-hydrogels.” FEBS Lett 581, no. 22 (September 4, 2007): 4172–78. https://doi.org/10.1016/j.febslet.2007.07.049.

Hwang, Nathaniel S., Shyni Varghese, Christopher Puleo, Zijun Zhang, and Jennifer Elisseeff. “Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells.” J Cell Physiol 212, no. 2 (August 2007): 281–84. https://doi.org/10.1002/jcp.21052.

Wang, Dong-An, Shyni Varghese, Blanka Sharma, Iossif Strehin, Sara Fermanian, Justin Gorham, D Howard Fairbrother, Brett Cascio, and Jennifer H. Elisseeff. “Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration.” Nat Mater 6, no. 5 (May 2007): 385–92. https://doi.org/10.1038/nmat1890.

Hwang, Nathaniel S., Shyni Varghese, and Jennifer Elisseeff. “Cartilage tissue engineering: Directed differentiation of embryonic stem cells in three-dimensional hydrogel culture.” Methods Mol Biol 407 (2007): 351–73. https://doi.org/10.1007/978-1-59745-536-7_24.

Varghese, S., P. Theprungsirikul, S. Sahani, N. Hwang, K. J. Yarema, and J. H. Elisseeff. “Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression.” Osteoarthritis Cartilage 15, no. 1 (January 2007): 59–68. https://doi.org/10.1016/j.joca.2006.06.008.

2006

Varghese, S., and J. H. Elisseeff. Hydrogels for musculoskeletal tissue engineering. Vol. 203, 2006. https://doi.org/10.1007/12_072.

Hwang, Nathaniel S., Shyni Varghese, Parnduangjai Theprungsirikul, Adam Canver, and Jennifer Elisseeff. “Enhanced chondrogenic differentiation of murine embryonic stem cells in hydrogels with glucosamine.” Biomaterials 27, no. 36 (December 2006): 6015–23. https://doi.org/10.1016/j.biomaterials.2006.06.033.

Hwang, Nathaniel S., Shyni Varghese, Zijun Zhang, and Jennifer Elisseeff. “Chondrogenic differentiation of human embryonic stem cell-derived cells in arginine-glycine-aspartate-modified hydrogels.” Tissue Eng 12, no. 9 (September 2006): 2695–2706. https://doi.org/10.1089/ten.2006.12.2695.