|Title||Rationally Designed Anisotropic and Auxetic Hydrogel Patches for Adaptation to Dynamic Organs|
|Publication Type||Journal Article|
|Year of Publication||2022|
|Authors||P Chansoria, J Blackwell, EL Etter, EE Bonacquisti, N Jasiewicz, T Neal, SA Kamal, J Hoque, S Varghese, T Egan, and J Nguyen|
|Journal||Advanced Functional Materials|
Current hydrogel or fabric patches for organ repair are generally not designed to conform to the complex mechanics of dynamic organs such as the lung or heart. This study presents a new, biocompatible and bilayered, hydrogel-based patch platform, consisting of a non-fouling top layer and a cell adhesive bottom layer, that caters to the anisotropic and auxetic characteristics of dynamic organs. Integrated computational and experimental studies are used to screen over 116 unique anisotropic-auxetic architectures to establish design rules and tailor the patches to a broad range of target organ dynamics. The patches are then validated in ex vivo and in vivo animal models, where the auxetic patches outperformed non-auxetic patches in conforming to the volumetric dilation-contraction of dynamic organs. To further expand the functionality of the auxetic patch platform, novel hole-filling auxetic patches are developed. These hole-filling patches composited with fibrin robustly reduce pulmonary air leakage in rats with surgically induced lung puncture. This is the first demonstration of a rational patch design framework that features both anisotropic and auxetic properties to cater to a wide range of organ dynamics. These studies pave the way for future clinical development of biomimetic patches.
|Short Title||Advanced Functional Materials|