Publications

2017

Kang, H., Y. R. V. Shih, V. Rao, and S. Varghese. “Biomineralized matrices as intelligent scaffolds for bone tissue regeneration.” In Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, 2nd Edition, 59–84, 2017. https://doi.org/10.1201/9781315364698.

2016

González-Díaz, E. C., and S. Varghese. “Hydrogels as extracellular matrix analogs.” Gels 2, no. 3 (September 1, 2016). https://doi.org/10.3390/gels2030020.

Kang, Heemin, Yu-Ru V. Shih, Manando Nakasaki, Harsha Kabra, and Shyni Varghese. “Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts.” Sci Adv 2, no. 8 (August 2016): e1600691. https://doi.org/10.1126/sciadv.1600691.

Mo, Alexander H., Preston B. Landon, Karla Santacruz Gomez, Heemin Kang, Joon Lee, Chen Zhang, Woraphong Janetanakit, et al. “Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing.” Nanoscale 8, no. 23 (June 9, 2016): 11840–50. https://doi.org/10.1039/c6nr02445a.

Aung, Aereas, Jomkuan Theprungsirikul, Han Liang Lim, and Shyni Varghese. “Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform.” Lab Chip 16, no. 10 (May 21, 2016): 1886–98. https://doi.org/10.1039/c6lc00184j.

Wen, Cai, Heemin Kang, Yu-Ru V. Shih, YongSung Hwang, and Shyni Varghese. “In vivo comparison of biomineralized scaffold-directed osteogenic differentiation of human embryonic and mesenchymal stem cells.” Drug Deliv Transl Res 6, no. 2 (April 2016): 121–31. https://doi.org/10.1007/s13346-015-0242-2.

Sharma, Blanka, and Shyni Varghese. “Progress in orthopedic biomaterials and drug delivery.” Drug Deliv Transl Res 6, no. 2 (April 2016): 75–76. https://doi.org/10.1007/s13346-016-0288-9.

Aung, Aereas, Ivneet Singh Bhullar, Jomkuan Theprungsirikul, Shruti Krishna Davey, Han Liang Lim, Yu-Jui Chiu, Xuanyi Ma, et al. “3D cardiac μtissues within a microfluidic device with real-time contractile stress readout.” Lab Chip 16, no. 1 (January 7, 2016): 153–62. https://doi.org/10.1039/c5lc00820d.

Seale, N. M., and S. Varghese. “Biomaterials for pluripotent stem cell engineering: From fate determination to vascularization.” Journal of Materials Chemistry B 4, no. 20 (January 1, 2016): 3454–63. https://doi.org/10.1039/c5tb02658j.

Kar, Mrityunjoy, Yu-Ru Vernon Shih, Daniel Ortiz Velez, Pedro Cabrales, and Shyni Varghese. “Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery.” Biomaterials 77 (January 2016): 186–97. https://doi.org/10.1016/j.biomaterials.2015.11.018.

2015

Davey, Shruti Krishna, Aereas Aung, Gaurav Agrawal, Han Liang Lim, Mrityunjoy Kar, and Shyni Varghese. “Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models.” Tissue Eng Part C Methods 21, no. 11 (November 2015): 1188–96. https://doi.org/10.1089/ten.TEC.2015.0179.

Nakasaki, Manando, Yongsung Hwang, Yun Xie, Sunny Kataria, Rupali Gund, Edries Y. Hajam, Rekha Samuel, et al. “The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis.” Nat Commun 6 (October 15, 2015): 8574. https://doi.org/10.1038/ncomms9574.

Shih, Yu-Ru, Ameya Phadke, Tomonori Yamaguchi, Heemin Kang, Nozomu Inoue, Koichi Masuda, and Shyni Varghese. “Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment.” Acta Biomater 19 (June 2015): 1–9. https://doi.org/10.1016/j.actbio.2015.03.017.

Kang, Heemin, Yu-Ru V. Shih, and Shyni Varghese. “Biomineralized matrices dominate soluble cues to direct osteogenic differentiation of human mesenchymal stem cells through adenosine signaling.” Biomacromolecules 16, no. 3 (March 9, 2015): 1050–61. https://doi.org/10.1021/acs.biomac.5b00099.

Kim, Hwan D., Jiseung Heo, Yongsung Hwang, Seon-Yeong Kwak, Ok Kyu Park, Hyunbum Kim, Shyni Varghese, and Nathaniel S. Hwang. “Extracellular-matrix-based and Arg-Gly-Asp-modified photopolymerizing hydrogels for cartilage tissue engineering.” Tissue Eng Part A 21, no. 3–4 (February 2015): 757–66. https://doi.org/10.1089/ten.TEA.2014.0233.

Kabra, Harsha, Yongsung Hwang, Han Liang Lim, Mrityunjoy Kar, Gaurav Arya, and Shyni Varghese. “Biomimetic Material-Assisted Delivery of Human Embryonic Stem Cell Derivatives for Enhanced In Vivo Survival and Engraftment.” ACS Biomater Sci Eng 1, no. 1 (January 12, 2015): 7–12. https://doi.org/10.1021/ab500021a.

Rao, V., Y. R. V. Shih, H. Kang, H. Kabra, and S. Varghese. “Adenosine signaling mediates osteogenic differentiation of human embryonic stem cells on mineralized matrices.” Frontiers in Bioengineering and Biotechnology 3, no. NOV (January 1, 2015). https://doi.org/10.3389/fbioe.2015.00185.

2014

Aung, Aereas, Young N. Seo, Shaoying Lu, Yingxiao Wang, Colin Jamora, Juan C. del Álamo, and Shyni Varghese. “3D traction stresses activate protease-dependent invasion of cancer cells.” Biophys J 107, no. 11 (December 2, 2014): 2528–37. https://doi.org/10.1016/j.bpj.2014.07.078.

Kang, Heemin, Yu-Ru V. Shih, Yongsung Hwang, Cai Wen, Vikram Rao, Timothy Seo, and Shyni Varghese. “Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells.” Acta Biomater 10, no. 12 (December 2014): 4961–70. https://doi.org/10.1016/j.actbio.2014.08.010.

Kang, J., H. M. Park, Y. W. Kim, Y. H. Kim, S. Varghese, H. K. Seok, Y. G. Kim, and S. H. Kim. “Control of mesenchymal stem cell phenotype and differentiation depending on cell adhesion mechanism.” Eur Cell Mater 28 (November 25, 2014): 387–403. https://doi.org/10.22203/ecm.v028a27.

Kang, H., C. Wen, Y. Hwang, Y. R. V. Shih, M. Kar, S. W. Seo, and S. Varghese. “Biomineralized matrix-assisted osteogenic differentiation of human embryonic stem cells.” Journal of Materials Chemistry B 2, no. 34 (September 14, 2014): 5676–88. https://doi.org/10.1039/c4tb00714j.

Hwang, Yongsung, Samuel Suk, Yu-Ru Vernon Shih, Timothy Seo, Bin Du, Yun Xie, Ziyang Li, and Shyni Varghese. “WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment.” Sci Rep 4 (August 1, 2014): 5916. https://doi.org/10.1038/srep05916.

Caro-Diaz, E. J. E., A. Aung, J. Xu, S. Varghese, and E. A. Theodorakis. “Fusarisetins: structure-function studies on a novel class of cell migration inhibitors.” Organic Chemistry Frontiers 1, no. 2 (April 1, 2014): 135–39. https://doi.org/10.1039/c3qo00067b.

Shih, Yu-Ru V., YongSung Hwang, Ameya Phadke, Heemin Kang, Nathaniel S. Hwang, Eduardo J. Caro, Steven Nguyen, et al. “Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling.” Proc Natl Acad Sci U S A 111, no. 3 (January 21, 2014): 990–95. https://doi.org/10.1073/pnas.1321717111.

Lim, H. L., Y. Hwang, M. Kar, and S. Varghese. “Smart hydrogels as functional biomimetic systems.” Biomaterials Science 2, no. 5 (January 1, 2014): 603–18. https://doi.org/10.1039/c3bm60288e.