Publications

Liu, Mengqian, Manando Nakasaki, Yu-Ru Vernon Shih, and Shyni Varghese. “Effect of age on biomaterial-mediated in situ bone tissue regeneration.” Acta Biomater 78 (September 15, 2018): 329–40. https://doi.org/10.1016/j.actbio.2018.06.035.

Kang, Heemin, Yuze Zeng, and Shyni Varghese. “Functionally graded multilayer scaffolds for in vivo osteochondral tissue engineering.” Acta Biomater 78 (September 15, 2018): 365–77. https://doi.org/10.1016/j.actbio.2018.07.039.

Seale, Nailah, Suvasini Ramaswamy, Yu-Ru Shih, Inder Verma, and Shyni Varghese. “Macroporous Dual-compartment Hydrogels for Minimally Invasive Transplantation of Primary Human Hepatocytes.” Transplantation 102, no. 9 (September 2018): e373–81. https://doi.org/10.1097/TP.0000000000002330.

Moreno, Ana M., Xin Fu, Jie Zhu, Dhruva Katrekar, Yu-Ru V. Shih, John Marlett, Jessica Cabotaje, et al. “In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation.” Mol Ther 26, no. 7 (July 5, 2018): 1818–27. https://doi.org/10.1016/j.ymthe.2018.04.017.

González Díaz, Eva C., Yu-Ru V. Shih, Manando Nakasaki, Mengqian Liu, and Shyni Varghese. “Mineralized Biomaterials Mediated Repair of Bone Defects Through Endogenous Cells.” Tissue Eng Part A 24, no. 13–14 (July 2018): 1148–56. https://doi.org/10.1089/ten.TEA.2017.0297.

Seale, Nailah, Yuze Zeng, and S. Varghese. “Biomimetic Tissue Engineering for Musculoskeletal Tissues.” edited by Martin Stoddart, April Craft, Girish Pattappa, and Oliver Gardner, 2018. https://doi.org/10.1016/B978-0-12-811467-4.00009-7.

Kang, Heemin, Yu-Ru V. Shih, and Shyni Varghese. “Direct Conversion of Human Pluripotent Stem Cells to Osteoblasts With a Small Molecule.” Curr Protoc Stem Cell Biol 44 (February 28, 2018): 1F.21.1-1F.21.6. https://doi.org/10.1002/cpsc.44.

Varghese, Shyni. “Role of Matrix Proteins in Balancing Tissue Stiffness and Inflammation in Fibrosis.” In BIOPHYSICAL JOURNAL, 114:23A-23A. CELL PRESS, 2018.

Phadke, A., and S. Varghese. “Synthetic Biomaterials and Stem Cells for Connective Tissue Engineering.” In Molecular Cellular and Tissue Engineering, 36-36–18, 2018.

Hwang, Yongsung, Timothy Seo, Sara Hariri, Chulmin Choi, and Shyni Varghese. “Matrix Topographical Cue-Mediated Myogenic Differentiation of Human Embryonic Stem Cell Derivatives.” Polymers (Basel) 9, no. 11 (November 5, 2017). https://doi.org/10.3390/polym9110580.

Agrawal, Gaurav, Aereas Aung, and Shyni Varghese. “Skeletal muscle-on-a-chip: an in vitro model to evaluate tissue formation and injury.” Lab Chip 17, no. 20 (October 11, 2017): 3447–61. https://doi.org/10.1039/c7lc00512a.

Shih, Yu-Ru, Heemin Kang, Vikram Rao, Yu-Jui Chiu, Seong Keun Kwon, and Shyni Varghese. “In vivo engineering of bone tissues with hematopoietic functions and mixed chimerism.” Proc Natl Acad Sci U S A 114, no. 21 (May 23, 2017): 5419–24. https://doi.org/10.1073/pnas.1702576114.

Kang, H., Y. R. V. Shih, V. Rao, and S. Varghese. “Biomineralized matrices as intelligent scaffolds for bone tissue regeneration.” In Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine 2nd Edition, 59–84, 2017. https://doi.org/10.1201/9781315364698.

González-Díaz, E. C., and S. Varghese. “Hydrogels as extracellular matrix analogs.” Gels 2, no. 3 (September 1, 2016). https://doi.org/10.3390/gels2030020.

Kang, Heemin, Yu-Ru V. Shih, Manando Nakasaki, Harsha Kabra, and Shyni Varghese. “Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts.” Sci Adv 2, no. 8 (August 2016): e1600691. https://doi.org/10.1126/sciadv.1600691.

Mo, Alexander H., Preston B. Landon, Karla Santacruz Gomez, Heemin Kang, Joon Lee, Chen Zhang, Woraphong Janetanakit, et al. “Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing.” Nanoscale 8, no. 23 (June 9, 2016): 11840–50. https://doi.org/10.1039/c6nr02445a.

Aung, Aereas, Jomkuan Theprungsirikul, Han Liang Lim, and Shyni Varghese. “Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform.” Lab Chip 16, no. 10 (May 21, 2016): 1886–98. https://doi.org/10.1039/c6lc00184j.

Wen, Cai, Heemin Kang, Yu-Ru V. Shih, YongSung Hwang, and Shyni Varghese. “In vivo comparison of biomineralized scaffold-directed osteogenic differentiation of human embryonic and mesenchymal stem cells.” Drug Deliv Transl Res 6, no. 2 (April 2016): 121–31. https://doi.org/10.1007/s13346-015-0242-2.

Sharma, Blanka, and Shyni Varghese. “Progress in orthopedic biomaterials and drug delivery.” Drug Deliv Transl Res 6, no. 2 (April 2016): 75–76. https://doi.org/10.1007/s13346-016-0288-9.

Aung, Aereas, Ivneet Singh Bhullar, Jomkuan Theprungsirikul, Shruti Krishna Davey, Han Liang Lim, Yu-Jui Chiu, Xuanyi Ma, et al. “3D cardiac μtissues within a microfluidic device with real-time contractile stress readout.” Lab Chip 16, no. 1 (January 7, 2016): 153–62. https://doi.org/10.1039/c5lc00820d.

Kar, Mrityunjoy, Yu-Ru Vernon Shih, Daniel Ortiz Velez, Pedro Cabrales, and Shyni Varghese. “Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery.” Biomaterials 77 (January 2016): 186–97. https://doi.org/10.1016/j.biomaterials.2015.11.018.

Seale, N. M., and S. Varghese. “Biomaterials for pluripotent stem cell engineering: From fate determination to vascularization.” Journal of Materials Chemistry B 4, no. 20 (January 1, 2016): 3454–63. https://doi.org/10.1039/c5tb02658j.

Davey, Shruti Krishna, Aereas Aung, Gaurav Agrawal, Han Liang Lim, Mrityunjoy Kar, and Shyni Varghese. “Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models.” Tissue Eng Part C Methods 21, no. 11 (November 2015): 1188–96. https://doi.org/10.1089/ten.TEC.2015.0179.

Nakasaki, Manando, Yongsung Hwang, Yun Xie, Sunny Kataria, Rupali Gund, Edries Y. Hajam, Rekha Samuel, et al. “The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis.” Nat Commun 6 (October 15, 2015): 8574. https://doi.org/10.1038/ncomms9574.

Shih, Yu-Ru, Ameya Phadke, Tomonori Yamaguchi, Heemin Kang, Nozomu Inoue, Koichi Masuda, and Shyni Varghese. “Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment.” Acta Biomater 19 (June 2015): 1–9. https://doi.org/10.1016/j.actbio.2015.03.017.