Publications

Cigliola, Valentina, Adam Shoffner, Nutishia Lee, Jianhong Ou, Trevor J. Gonzalez, Jiaul Hoque, Clayton J. Becker, et al. “Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer.” Nat Commun 14, no. 1 (August 11, 2023): 4857. https://doi.org/10.1038/s41467-023-40486-5.

Gonzales, G., S. Zauscher, and S. Varghese. “Progress in the design and synthesis of viscosupplements for articular joint lubrication.” Current Opinion in Colloid and Interface Science 66 (August 1, 2023). https://doi.org/10.1016/j.cocis.2023.101708.

Newman, Hunter, and Shyni Varghese. “Extracellular adenosine signaling in bone health and disease.” Curr Opin Pharmacol 70 (June 2023): 102378. https://doi.org/10.1016/j.coph.2023.102378.

Aung, Aereas, Shruti K. Davey, Jomkuan Theprungsirikul, Vardhman Kumar, and Shyni Varghese. “Deciphering the Mechanics of Cancer Spheroid Growth in 3D Environments through Microfluidics Driven Mechanical Actuation.” Adv Healthc Mater 12, no. 14 (June 2023): e2201842. https://doi.org/10.1002/adhm.202201842.

Rana, Isha, Sunny Kataria, Tuan Lin Tan, Edries Yousaf Hajam, Deepak Kumar Kashyap, Dyuti Saha, Johan Ajnabi, et al. “Mindin (SPON2) Is Essential for Cutaneous Fibrogenesis in a Mouse Model of Systemic Sclerosis.” J Invest Dermatol 143, no. 5 (May 2023): 699-710.e10. https://doi.org/10.1016/j.jid.2022.10.011.

Kumar, Vardhman, David Kingsley, Sajeeshkumar Madhurakkat Perikamana, Pankaj Mogha, C Rory Goodwin, and Shyni Varghese. “Self-assembled innervated vasculature-on-a-chip to study nociception.” Biofabrication 15, no. 3 (April 13, 2023). https://doi.org/10.1088/1758-5090/acc904.

Yang, Ting, Ravikanth Velagapudi, Cuicui Kong, Unghyeon Ko, Vardhman Kumar, Paris Brown, Nathan O. Franklin, et al. “Protective effects of omega-3 fatty acids in a blood-brain barrier-on-chip model and on postoperative delirium-like behaviour in mice.” Br J Anaesth 130, no. 2 (February 2023): e370–80. https://doi.org/10.1016/j.bja.2022.05.025.

Hoque, Jiaul, Yuze Zeng, Hunter Newman, Gavin Gonzales, Cheryl Lee, and Shyni Varghese. “Microgel-Assisted Delivery of Adenosine to Accelerate Fracture Healing.” Acs Biomaterials Science & Engineering 8, no. 11 (November 2022): 4863–72. https://doi.org/10.1021/acsbiomaterials.2c00977.

Chansoria, P., J. Blackwell, E. L. Etter, E. E. Bonacquisti, N. Jasiewicz, T. Neal, S. A. Kamal, et al. “Rationally Designed Anisotropic and Auxetic Hydrogel Patches for Adaptation to Dynamic Organs.” Advanced Functional Materials 32, no. 43 (October 1, 2022). https://doi.org/10.1002/adfm.202207590.

Newman, Hunter, Jiaul Hoque, Yu-Ru V. Shih, Gabrielle Marushack, Unghyeon Ko, Gavin Gonzales, and Shyni Varghese. “pH-Sensitive nanocarrier assisted delivery of adenosine to treat osteoporotic bone loss.” Biomater Sci 10, no. 18 (September 13, 2022): 5340–55. https://doi.org/10.1039/d2bm00843b.

Bartholf DeWitt, Suzanne, Sarah Hoskinson Plumlee, Hailey E. Brighton, Dharshan Sivaraj, E. J. Martz, Maryam Zand, Vardhman Kumar, et al. “Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding.” Jci Insight 7, no. 17 (September 8, 2022). https://doi.org/10.1172/jci.insight.151583.

Madhurakkat Perikamana, S. K., N. Seale, J. Hoque, J. H. Ryu, V. Kumar, Y. V. Shih, and S. Varghese. “Molecularly Tailored Interface for Long-Term Xenogeneic Cell Transplantation.” Advanced Functional Materials 32, no. 4 (January 1, 2022). https://doi.org/10.1002/adfm.202108221.

Kumar, Vardhman, Sajeesh Kumar Madhurakkat Perikamana, Aleksandra Tata, Jiaul Hoque, Anna Gilpin, Purushothama Rao Tata, and Shyni Varghese. “An In Vitro Microfluidic Alveolus Model to Study Lung Biomechanics.” Front Bioeng Biotechnol 10 (2022): 848699. https://doi.org/10.3389/fbioe.2022.848699.

Ko, Ung Hyun, Vardhman Kumar, Benjamin Rosen, and Shyni Varghese. “Characterization of bending balloon actuators.” Front Robot Ai 9 (2022): 991748. https://doi.org/10.3389/frobt.2022.991748.

Gilpin, Anna, Yuze Zeng, Jiaul Hoque, Ji Hyun Ryu, Yong Yang, Stefan Zauscher, William Eward, and Shyni Varghese. “Self-Healing of Hyaluronic Acid to Improve In Vivo Retention and Function.” Adv Healthc Mater 10, no. 23 (December 2021): e2100777. https://doi.org/10.1002/adhm.202100777.

Newman, Hunter, Yuru Vernon Shih, and Shyni Varghese. “Resolution of inflammation in bone regeneration: From understandings to therapeutic applications.” Biomaterials 277 (October 2021): 121114. https://doi.org/10.1016/j.biomaterials.2021.121114.

Andress, Benjamin, Jason H. Kim, Hattie C. Cutcliffe, Annunziato Amendola, Adam P. Goode, Shyni Varghese, Louis E. DeFrate, and Amy L. McNulty. “Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding.” J Orthop Res 39, no. 10 (October 2021): 2177–86. https://doi.org/10.1002/jor.24954.

Kumar, Vardhman, Ung Hyun Ko, Yilong Zhou, Jiaul Hoque, Gaurav Arya, and Shyni Varghese. “Microengineered Materials with Self‐Healing Features for Soft Robotics.” Advanced Intelligent Systems 3, no. 7 (July 2021). https://doi.org/10.1002/aisy.202100005.

Hoque, Jiaul, Yu-Ru V. Shih, Yuze Zeng, Hunter Newman, Nivedita Sangaj, Neha Arjunji, and Shyni Varghese. “Bone targeting nanocarrier-assisted delivery of adenosine to combat osteoporotic bone loss.” Biomaterials 273 (June 2021): 120819. https://doi.org/10.1016/j.biomaterials.2021.120819.

Nayak, P., A. Colas, M. Mercola, S. Varghese, and S. Subramaniam. “Temporal mechanisms of myogenic specification in human induced pluripotent stem cells.” Sci Adv 7, no. 12 (March 2021). https://doi.org/10.1126/sciadv.abf7412.

Jabba, S. V., A. N. Diaz, A. I. Caceres, H. C. Erythropel, V. Kumar, S. Varghese, J. B. Zimmerman, and S. E. Jordt. “Cellular Respiratory Toxicity of Novel Flavor-Solvent Adducts in Electronic Cigarettes.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.

Moreno, Ana M., Xin Fu, Jie Zhu, Dhruva Katrekar, Yu-Ru V. Shih, John Marlett, Jessica Cabotaje, et al. “In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation.” Mol Ther 28, no. 8 (August 5, 2020): 1931. https://doi.org/10.1016/j.ymthe.2020.06.027.

Zeng, Yuze, Yu-Ru V. Shih, Gurpreet S. Baht, and Shyni Varghese. “In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing.” Adv Mater 32, no. 8 (February 2020): e1906022. https://doi.org/10.1002/adma.201906022.

Aung, Aereas, Vardhman Kumar, Jomkuan Theprungsirikul, Shruti K. Davey, and Shyni Varghese. “An Engineered Tumor-on-a-Chip Device with Breast Cancer-Immune Cell Interactions for Assessing T-cell Recruitment.” Cancer Res 80, no. 2 (January 15, 2020): 263–75. https://doi.org/10.1158/0008-5472.CAN-19-0342.

Shih, Yu-Ru V., Mengqian Liu, Seong Keun Kwon, Masayuki Iida, Ya Gong, Nivedita Sangaj, and Shyni Varghese. “Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss.” Sci Adv 5, no. 8 (August 2019): eaax1387. https://doi.org/10.1126/sciadv.aax1387.