Publications

Li, Jiaoni, Yu-Ru Vernon Shih, Huchen Tao, Mitchell Negus, Jeffrey Bohrer Guerra, and Shyni Varghese. “Extensive Periosteal Injury During Fracture Induces Long-Term Pain in Mice.” J Orthop Res 43, no. 6 (June 2025): 1155–63. https://doi.org/10.1002/jor.26067.

Natesh, N. R., and S. Varghese. “Advances and Challenges in Human 3D Solid Tumor Models.” Advanced Functional Materials 35, no. 20 (May 16, 2025). https://doi.org/10.1002/adfm.202419912.

Newman, Hunter, Yu-Ru V. Shih, Jiaul Hoque, Yuze Zeng, Naveen R. Natesh, Gavin Gonzales, Wendi Guo, et al. “Enabling adenosine signaling to promote aged fracture healing.” NPJ Regen Med 10, no. 1 (April 9, 2025): 18. https://doi.org/10.1038/s41536-025-00406-1.

Madhurakkat Perikamana, Sajeeshkumar, Hunter Newman, Yuru Vernon Shih, Lavonia Duncan, Hilal Ahmad Rather, Jiaoni Li, Ravikanth Velagapudi, Niccolò Terrando, and Shyni Varghese. “Depletion of senescent cells improves surgery-induced neuroinflammation in aged mice.” PNAS Nexus 4, no. 4 (April 2025): pgaf103. https://doi.org/10.1093/pnasnexus/pgaf103.

Shih, Yu-Ru V., Huchen Tao, Anna Gilpin, Yuan-Wen Lee, Sajeeshkumar Madhurakkat Perikamana, and Shyni Varghese. “Specialized pro-resolving mediator Maresin 1 attenuates pain in a mouse model of osteoarthritis.” Osteoarthritis Cartilage 33, no. 3 (March 2025): 341–50. https://doi.org/10.1016/j.joca.2024.10.018.

Husain, Irma, Holly Shah, Collin Z. Jordan, Naveen R. Natesh, Olivia K. Fay, Yanting Chen, Jamie R. Privratsky, et al. “Targeting allograft inflammatory factor 1 reprograms kidney macrophages to enhance repair.” J Clin Invest 135, no. 5 (January 21, 2025). https://doi.org/10.1172/JCI185146.

Pal, Asish, Praveen Kumar Vemula, and Shyni Varghese. “Festschrift issue of Nanoscale in honour of Santanu Bhattacharya.” Nanoscale 17, no. 2 (January 2, 2025): 613–15. https://doi.org/10.1039/d4nr90228a.

Gonzales, Gavin, Jiaul Hoque, Colin Kaeo, Stefan Zauscher, and Shyni Varghese. “Grafting of cationic molecules to hyaluronic acid improves adsorption and cartilage lubrication.” Biomater Sci 12, no. 18 (September 10, 2024): 4747–58. https://doi.org/10.1039/d4bm00532e.

Cottrill, Ethan, Zach Pennington, Nathan Sattah, Crystal Jing, Dave Salven, Eli Johnson, Max Downey, Shyni Varghese, Brett Rocos, and William Richardson. “Gene Therapy and Spinal Fusion: Systematic Review and Meta-Analysis of the Available Data.” World Neurosurg 186 (June 2024): 219-234.e4. https://doi.org/10.1016/j.wneu.2024.03.174.

Gonzales, Gavin, Jiaul Hoque, Anna Gilpin, Biswanath Maity, Stefan Zauscher, and Shyni Varghese. “Branched poly-l-lysine for cartilage penetrating carriers.” Bioeng Transl Med 9, no. 3 (May 2024): e10612. https://doi.org/10.1002/btm2.10612.

Hainline, Kelly M., Helena Freire Haddad, Anna Gilpin, Elizabeth J. Curvino, Shyni Varghese, and Joel H. Collier. “Active immunotherapy for C5a-mediated inflammation using adjuvant-free self-assembled peptide nanofibers.” Acta Biomater 179 (April 15, 2024): 83–94. https://doi.org/10.1016/j.actbio.2024.02.042.

Price, Meghan J., Annee D. Nguyen, Corinne Haines, César D. Baëta, Jovita Byemerwa, Debarati Murkajee, Sandeep Artham, et al. “UDP-6-glucose dehydrogenase in hormonally responsive breast cancers.” BioRxiv, March 21, 2024. https://doi.org/10.1101/2024.03.20.585919.

Natesh, Naveen R., Pankaj Mogha, Alan Chen, Scott J. Antonia, and Shyni Varghese. “Differential roles of normal and lung cancer-associated fibroblasts in microvascular network formation.” APL Bioeng 8, no. 1 (March 2024): 016120. https://doi.org/10.1063/5.0188238.

Subramaniam, Shankar, Metin Akay, Mark A. Anastasio, Vasudev Bailey, David Boas, Paolo Bonato, Ashutosh Chilkoti, et al. “Grand Challenges at the Interface of Engineering and Medicine.” IEEE Open J Eng Med Biol 5 (2024): 1–13. https://doi.org/10.1109/OJEMB.2024.3351717.

Shih, Yu-Ru V., David Kingsley, Hunter Newman, Jiaul Hoque, Ankita Gupta, B Duncan X. Lascelles, and Shyni Varghese. “Multi-Functional Small Molecule Alleviates Fracture Pain and Promotes Bone Healing.” Adv Sci (Weinh) 10, no. 36 (December 2023): e2303567. https://doi.org/10.1002/advs.202303567.

Guo, Wendi, Jiaul Hoque, Carolina J. Garcia Garcia, Kassandra V. Spiller, Abigail P. Leinroth, Vijitha Puviindran, Cahil K. Potnis, et al. “Radiation-induced bone loss in mice is ameliorated by inhibition of HIF-2α in skeletal progenitor cells.” Sci Transl Med 15, no. 724 (November 29, 2023): eabo5217. https://doi.org/10.1126/scitranslmed.abo5217.

Cigliola, Valentina, Adam Shoffner, Nutishia Lee, Jianhong Ou, Trevor J. Gonzalez, Jiaul Hoque, Clayton J. Becker, et al. “Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer.” Nat Commun 14, no. 1 (August 11, 2023): 4857. https://doi.org/10.1038/s41467-023-40486-5.

Gonzales, G., S. Zauscher, and S. Varghese. “Progress in the design and synthesis of viscosupplements for articular joint lubrication.” Current Opinion in Colloid and Interface Science 66 (August 1, 2023). https://doi.org/10.1016/j.cocis.2023.101708.

Aung, Aereas, Shruti K. Davey, Jomkuan Theprungsirikul, Vardhman Kumar, and Shyni Varghese. “Deciphering the Mechanics of Cancer Spheroid Growth in 3D Environments through Microfluidics Driven Mechanical Actuation.” Adv Healthc Mater 12, no. 14 (June 2023): e2201842. https://doi.org/10.1002/adhm.202201842.

Newman, Hunter, and Shyni Varghese. “Extracellular adenosine signaling in bone health and disease.” Curr Opin Pharmacol 70 (June 2023): 102378. https://doi.org/10.1016/j.coph.2023.102378.

Rana, Isha, Sunny Kataria, Tuan Lin Tan, Edries Yousaf Hajam, Deepak Kumar Kashyap, Dyuti Saha, Johan Ajnabi, et al. “Mindin (SPON2) Is Essential for Cutaneous Fibrogenesis in a Mouse Model of Systemic Sclerosis.” J Invest Dermatol 143, no. 5 (May 2023): 699-710.e10. https://doi.org/10.1016/j.jid.2022.10.011.

Kumar, Vardhman, David Kingsley, Sajeeshkumar Madhurakkat Perikamana, Pankaj Mogha, C Rory Goodwin, and Shyni Varghese. “Self-assembled innervated vasculature-on-a-chip to study nociception.” Biofabrication 15, no. 3 (April 13, 2023). https://doi.org/10.1088/1758-5090/acc904.

Yang, Ting, Ravikanth Velagapudi, Cuicui Kong, Unghyeon Ko, Vardhman Kumar, Paris Brown, Nathan O. Franklin, et al. “Protective effects of omega-3 fatty acids in a blood-brain barrier-on-chip model and on postoperative delirium-like behaviour in mice.” Br J Anaesth 130, no. 2 (February 2023): e370–80. https://doi.org/10.1016/j.bja.2022.05.025.

Varghese, Shyni. “BIOENGINEERED PLATFORM TO STUDY IMMUNE-CANCER CELL INTERACTIONS EX VIVO.” In TISSUE ENGINEERING PART A, 29:138–138, 2023.

Guo, Wendi, Jiaul Hoque, Carolina Garcia, Kassandra Spiller, Tara Fujimoto, Denae Johnson, Abagail Delahoussaye, et al. “Targeting HIF-2 in the bone marrow microenvironment as a radioprotective strategy for bone.” In JOURNAL OF BONE AND MINERAL RESEARCH, 38:3–3, 2023.