Publications

Andress, Benjamin, Jason H. Kim, Hattie C. Cutcliffe, Annunziato Amendola, Adam P. Goode, Shyni Varghese, Louis E. DeFrate, and Amy L. McNulty. “Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding.” J Orthop Res 39, no. 10 (October 2021): 2177–86. https://doi.org/10.1002/jor.24954.

Newman, Hunter, Yuru Vernon Shih, and Shyni Varghese. “Resolution of inflammation in bone regeneration: From understandings to therapeutic applications.” Biomaterials 277 (October 2021): 121114. https://doi.org/10.1016/j.biomaterials.2021.121114.

Kumar, Vardhman, Ung Hyun Ko, Yilong Zhou, Jiaul Hoque, Gaurav Arya, and Shyni Varghese. “Microengineered Materials with Self‐Healing Features for Soft Robotics.” Advanced Intelligent Systems 3, no. 7 (July 2021). https://doi.org/10.1002/aisy.202100005.

Hoque, Jiaul, Yu-Ru V. Shih, Yuze Zeng, Hunter Newman, Nivedita Sangaj, Neha Arjunji, and Shyni Varghese. “Bone targeting nanocarrier-assisted delivery of adenosine to combat osteoporotic bone loss.” Biomaterials 273 (June 2021): 120819. https://doi.org/10.1016/j.biomaterials.2021.120819.

Nayak, P., A. Colas, M. Mercola, S. Varghese, and S. Subramaniam. “Temporal mechanisms of myogenic specification in human induced pluripotent stem cells.” Sci Adv 7, no. 12 (March 2021). https://doi.org/10.1126/sciadv.abf7412.

Jabba, S. V., A. N. Diaz, A. I. Caceres, H. C. Erythropel, V. Kumar, S. Varghese, J. B. Zimmerman, and S. E. Jordt. “Cellular Respiratory Toxicity of Novel Flavor-Solvent Adducts in Electronic Cigarettes.” In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 203, 2021.

Moreno, Ana M., Xin Fu, Jie Zhu, Dhruva Katrekar, Yu-Ru V. Shih, John Marlett, Jessica Cabotaje, et al. “In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation.” Mol Ther 28, no. 8 (August 5, 2020): 1931. https://doi.org/10.1016/j.ymthe.2020.06.027.

Zeng, Yuze, Yu-Ru V. Shih, Gurpreet S. Baht, and Shyni Varghese. “In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing.” Adv Mater 32, no. 8 (February 2020): e1906022. https://doi.org/10.1002/adma.201906022.

Aung, Aereas, Vardhman Kumar, Jomkuan Theprungsirikul, Shruti K. Davey, and Shyni Varghese. “An Engineered Tumor-on-a-Chip Device with Breast Cancer-Immune Cell Interactions for Assessing T-cell Recruitment.” Cancer Res 80, no. 2 (January 15, 2020): 263–75. https://doi.org/10.1158/0008-5472.CAN-19-0342.

Shih, Yu-Ru V., Mengqian Liu, Seong Keun Kwon, Masayuki Iida, Ya Gong, Nivedita Sangaj, and Shyni Varghese. “Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss.” Sci Adv 5, no. 8 (August 2019): eaax1387. https://doi.org/10.1126/sciadv.aax1387.

Zeng, Yuze, Jiaul Hoque, and Shyni Varghese. “Biomaterial-assisted local and systemic delivery of bioactive agents for bone repair.” Acta Biomater 93 (July 15, 2019): 152–68. https://doi.org/10.1016/j.actbio.2019.01.060.

Serrano, Ricardo, Aereas Aung, Yi-Ting Yeh, Shyni Varghese, Juan C. Lasheras, and Juan C. Del Álamo. “Three-Dimensional Monolayer Stress Microscopy.” Biophys J 117, no. 1 (July 9, 2019): 111–28. https://doi.org/10.1016/j.bpj.2019.03.041.

Shih, Yuru Vernon, and Shyni Varghese. “Tissue engineered bone mimetics to study bone disorders ex vivo: Role of bioinspired materials.” Biomaterials 198 (April 2019): 107–21. https://doi.org/10.1016/j.biomaterials.2018.06.005.

Katrekar, Dhruva, Genghao Chen, Dario Meluzzi, Ashwin Ganesh, Atharv Worlikar, Yu-Ru Shih, Shyni Varghese, and Prashant Mali. “In vivo RNA editing of point mutations via RNA-guided adenosine deaminases.” Nat Methods 16, no. 3 (March 2019): 239–42. https://doi.org/10.1038/s41592-019-0323-0.

Kumar, Vardhman, and Shyni Varghese. “Ex Vivo Tumor-on-a-Chip Platforms to Study Intercellular Interactions within the Tumor Microenvironment.” Adv Healthc Mater 8, no. 4 (February 2019): e1801198. https://doi.org/10.1002/adhm.201801198.

Hoque, Jiaul, Nivedita Sangaj, and Shyni Varghese. “Stimuli-Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine.” Macromol Biosci 19, no. 1 (January 2019): e1800259. https://doi.org/10.1002/mabi.201800259.

Ryu, Ji Hyun, Gyeong Jin Lee, Yu-Ru V. Shih, Tae-Il Kim, and Shyni Varghese. “Phenylboronic Acid-polymers for Biomedical Applications.” Curr Med Chem 26, no. 37 (2019): 6797–6816. https://doi.org/10.2174/0929867325666181008144436.

Liu, Mengqian, Manando Nakasaki, Yu-Ru Vernon Shih, and Shyni Varghese. “Effect of age on biomaterial-mediated in situ bone tissue regeneration.” Acta Biomater 78 (September 15, 2018): 329–40. https://doi.org/10.1016/j.actbio.2018.06.035.

Kang, Heemin, Yuze Zeng, and Shyni Varghese. “Functionally graded multilayer scaffolds for in vivo osteochondral tissue engineering.” Acta Biomater 78 (September 15, 2018): 365–77. https://doi.org/10.1016/j.actbio.2018.07.039.

Seale, Nailah, Suvasini Ramaswamy, Yu-Ru Shih, Inder Verma, and Shyni Varghese. “Macroporous Dual-compartment Hydrogels for Minimally Invasive Transplantation of Primary Human Hepatocytes.” Transplantation 102, no. 9 (September 2018): e373–81. https://doi.org/10.1097/TP.0000000000002330.

Moreno, Ana M., Xin Fu, Jie Zhu, Dhruva Katrekar, Yu-Ru V. Shih, John Marlett, Jessica Cabotaje, et al. “In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation.” Mol Ther 26, no. 7 (July 5, 2018): 1818–27. https://doi.org/10.1016/j.ymthe.2018.04.017.

González Díaz, Eva C., Yu-Ru V. Shih, Manando Nakasaki, Mengqian Liu, and Shyni Varghese. “Mineralized Biomaterials Mediated Repair of Bone Defects Through Endogenous Cells.” Tissue Eng Part A 24, no. 13–14 (July 2018): 1148–56. https://doi.org/10.1089/ten.TEA.2017.0297.

Seale, Nailah, Yuze Zeng, and S. Varghese. “Biomimetic Tissue Engineering for Musculoskeletal Tissues.” edited by Martin Stoddart, April Craft, Girish Pattappa, and Oliver Gardner, 2018. https://doi.org/10.1016/B978-0-12-811467-4.00009-7.

Kang, Heemin, Yu-Ru V. Shih, and Shyni Varghese. “Direct Conversion of Human Pluripotent Stem Cells to Osteoblasts With a Small Molecule.” Curr Protoc Stem Cell Biol 44 (February 28, 2018): 1F.21.1-1F.21.6. https://doi.org/10.1002/cpsc.44.

Varghese, Shyni. “Role of Matrix Proteins in Balancing Tissue Stiffness and Inflammation in Fibrosis.” In BIOPHYSICAL JOURNAL, 114:23A-23A. CELL PRESS, 2018.